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Epigenetics and gene expression in parasites

Eradication of latent toxoplasmosis

​We are accepting applications for postdoctoral fellows interested in the study of Toxoplasma gondii parasites. Toxoplasma is an opportunistic pathogen that causes disease in congenitally infected infants and immune compromised patients. Currently untreatable, the latent tissue cysts formed by the parasite are central to pathogenesis, transmission, and behavioral changes in the host. We use state-of-the-art multi-disciplinary approaches to interrogate how the parasite reprograms its genome to convert to the latent stage of infection.

One project involves the study of lysine acetyltransferases that mediate epigenetic changes required to orchestrate development into latent cysts. The other project involves the study of novel experimental drug therapies aimed at eradicating tissue cysts from infected hosts.

These are NIH-funded positions in the laboratory of Bill Sullivan (http://www.sullivanlab.com/). These positions require a Ph.D., expertise in cell/molecular biology or biochemistry, and excellent communication skills (speaking and writing English). Experience with mouse models of infection is a plus. Submit CV and contact information for three references to wjsulliv@iu.edu.


Our laboratory is a part of the “BIP” (Biology of Intracellular Pathogens) group at the Indiana University School of Medicine (IUSM): http://wjsulliv.wix.com/bipatiu. Located in downtown Indianapolis, IUSM is the largest medical school in the US and boasts an outstanding intellectual atmosphere and core facilities. IUSM was nationally ranked in the Top 30 Best Places to Work for Postdocs. IUSM is an equal opportunity employer.

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