BIP@IUSM
BIP at IUSM
the Biology of Intracellular Pathogens
at Indiana University School of Medicine
LATEST NEWS
New publication: "Rebound of cyst number following discontinuation of guanabenz treatment for latent toxoplasmosis" in MBP (September, 2021)
New publication: "m6A RNA methylation facilitates pre-mRNA 3'-end formation and is essential for viability of Toxoplasma gondii" in PLOS Pathogens (July, 2021)
New publication: "Making it personal: science communication for the masses' in Trends in Parasitology (June, 2021)
New publication: "TgIF2K-B Is an eIF2α Kinase in Toxoplasma gondii That Responds to Oxidative Stress and Optimizes Pathogenicity" in mBio. (January, 2021)
New publication: "Host sensing and signal transduction during Toxoplasma stage conversion" in Molecular Microbiology (October, 2020)
New publication: "Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season" in Nature Medicine (October, 2020)
New publication: "Toxoplasma gondii AP2XII-2 Contributes to Proper Progression through S-Phase of the Cell Cycle" in mSphere (September, 2020)
New publication: "Toxoplasma gondii Co-opts the Unfolded Protein Response To Enhance Migration and Dissemination of Infected Host Cells" in mBio (July, 2020)
New publication: "Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19" in Frontiers Immunology (June, 2020)
New publication: "Hydroxyurea dose escalation for sickle cell anemia in sub-Sahara Africa" in New England Journal of Medicine (June, 2020)
Dibya Datta was awarded a Wells Center Translational Grant: "Tracking Asymptomatic COVID-19 Through Indianapolis Communities 2 [TACTIC 2]" (June, 2020)
New publication: "Efficacy of Guanabenz Combination Therapy Against Chronic Toxoplasmosis Across Multiple Mouse Strains" in Antimicrobial Agents & Chemotherapy (June, 2020)
New publication: "Longitudinal analysis of naturally acquired PfEMP1 CIDR domain variant antibodies identifies associations with malaria protection" in JCI Insight (May, 2020)
New publication: "Evaluating the GCN5b bromodomain as a novel therapeutic target against the parasite Toxoplasma gondii" in Exp Parasitol (March, 2020)
Dr. Sullivan was awarded an R21 grant from NIH, “Eradicating latent toxoplasmosis” (March, 2020)
Dr. Arrizabalaga was awarded an R01 grant from NIH, "Regulation of mitochondrial morphodynamics in Toxoplasma gondii" (March, 2020)
New publication: "The Secreted Acid Phosphatase Domain-Containing GRA44 from Toxoplasma gondii Is Required for c-Myc Induction in Infected Cells" in mSphere (February, 2020)
New publication: "Identification of Fis1 Interactors in Toxoplasma gondii Reveals a Novel Protein Required for Peripheral Distribution of the Mitochondrion" in mBio (February, 2020)
New publication: "Coxiella burnetii Type 4B Secretion System-dependent manipulation of endolysosomal maturation is required for bacterial growth" in PLOS Path (December, 2019)
Mike Holmes received a Postdoctoral Fellowship from the American Heart Association (December, 2019)
Jen Martynowicz successfully defended her PhD thesis (December, 2019)
New publication: "Repositioning of guanabenz in conjugation with gold and silver nanoparticles against pathogenic amoebae Acanthamoeba castellanii and Naegleria fowleri" in ACS Infect Dis. (October, 2019)
New publication: "A molecular signature in blood reveals a role for p53 in regulating malaria-induced inflammation" in Immunity. (October, 2019)
New publication: "Phosphorylation of Eukaryotic Initiation Factor 2-α in Response to Endoplasmic Reticulum and Nitrosative Stress in the human protozoan parasite, Entamoeba histolytica" in Mol Biochem Parasitol. (October, 2019)
New publication: "A novel GCN5b lysine acetyltransferase complex associates with distinct transcription factors in the protozoan parasite Toxoplasma gondii" in Mol Biochem Parasitol. (August, 2019)
New publication: "Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii" in PLOS Pathogens. (June, 2019)
New publication: "Simultaneous Ribosome Profiling of Human Host Cells Infected with Toxoplasma gondii" in mSphere. (June, 2019)
New publication: "Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria" BMC Med. (May, 2019)
New publication: "Elevated cerebrospinal fluid tau protein concentrations on admission are associated with long-term neurologic and cognitive impairment in Ugandan children with cerebral malaria" in Clin Infect Dis. (May, 2019)
New publication: "Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii" in Parasit Vectors. (May, 2019)
New publication: "Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation" in MBio. (April, 2019)
Article in The Conversation.
Chandy John was awarded a grant from Indiana CTSI Global Health Research: "Binomic characterization of malaria vectors in the highlands of Kenya - identification of gaps in protection and drivers of transmission in association with current intervention methods"
New publication: "A plasma membrane localized protein phosphatase in Toxoplasma gondii, PPM5C, regulates attachment to host cells." in Sci Reports. (April, 2019)
Dr. Sullivan was awarded an R21 grant from NIH, “Epitranscriptomics in the AIDS-opportunistic pathogen Toxoplasma gondii” (March, 2019)
New publication: "What causes severe malaria and its complications in children? Lessons learned over the past 15 years." in BMC Med. (March, 2019)
New publication: "Evaluation of ATM Kinase Inhibitor KU-55933 as Potential Anti-Toxoplasma gondii Agent." in Front Cell Infect Microbiol. (February, 2019)
Dhritiman Samanta (Gilk Lab) was awarded a postdoctoral fellowship award from AHA: "Elucidating the mechanisms behind Coxiella burnetii regulation of vesicular pH" (November, 2018)
Irene Heredero-Bermejo (Arrizabalaga Lab) was awarded a postdoctoral fellowship award from AHA: "Characterization of TgDrpC, an atypical dynamin related protein in Toxoplasma gondii" (November, 2018)
New publication: "TgDrpC, an atypical dynamin-related protein in Toxoplasma gondii, is associated with vesicular transport factors and parasite division" in Molecular Microbiology (October, 2018)
Tatiana Clemente (Gilk Lab) was awarded a Travel Grant to attend and deliver an oral presentation at the 25th Annual Midwest Microbial Pathogenesis Conference (September, 2018)
Jen Martynowicz (Sullivan Lab) received the 2019 Madri Scholarship (September, 2018)
New publication: "Effects of PERK eIF2α kinase inhibitor against Toxoplasma gondii" in Antimicrobial Agents and Chemotherapy (September, 2018)
Gustavo Arrizabalaga and Travis Jerde were awarded an NIH R21 grant: "Prostate pathogenesis during Toxoplasma gondii infection" (August, 2018)
Giselle Lima (John Lab) was selected for a T32 award, “Multiplex Molecular Tool for Diagnosis of Five Human Malaria Species in Uganda and Kenya.” (August, 2018)
New publication: "Whole-blood transcriptional signatures composed of erythropoietic and Nrf2-regulated genes differ between cerebral malaria and severe malarial anemia" in Journal of Infectious Diseases (August, 2018)
Tuan Tran was awarded a Doris Duke Charitable Foundation Clinical Scientist Development Award "Systems analysis to understand protective immunity induced by an attenuated sporozoite malaria vaccine in African infants" (August, 2018)
New publication: "Coxiella burnetii blocks intracellular IL-17 signaling in macrophages" in Infection and Immunity (July, 2018)
New publication: "Whole-blood transcriptional signatures composed of erythropoietic and Nrf2-regulated genes differ between cerebral malaria and severe malarial anemia" in Journal of Infectious Diseases (July, 2018)
Tuan Tran was awarded a Showalter Young Investigator Award: Investigating the effects of Plasmodium falciparum on the epigenetic landscape of human immune cells (May, 2018)
Jen Martynowicz (Sullivan Lab) was awarded a travel grant to present at the Gordon Research Conference Biology of Host-Parasite Interactions (May, 2018)
Stacey Gilk was awarded an NIH R21 grant "Coxiella survival mechanisms in the acidic intracellular niche" (May, 2018)
Gustavo Arrizabalaga and Travis Jerde were awarded a NIH R21 grant "Prostate pathogenesis during Toxoplasma gondii infection" (May, 2018)
New publication: "Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis" in PLOS Pathogens (May, 2018)
Stacey Gilk was awarded a NIH R01 grant "Coxiella manipulation of cholesterol in the intracellular niche" (May, 2018)
Stacey Gilk was awarded a 2018 IUSM Trustees Teaching Award (May, 2018)
New publication: "Altering lipid droplet homeostasis affects Coxiella burnetii intracellular growth" in PLOS ONE (May, 2018)
Vicki Jeffers wrote a piece for the Royal Society of Biology: "Parasite Puppetmasters" (April, 2018)
New publication: "A latent ability to persist: differentiation in Toxoplasma gondii" in Cell Mol Life Sci (April, 2018)
New publication: "TgTKL1 Is a Unique Plant-Like Nuclear Kinase That Plays an Essential Role in Acute Toxoplasmosis" in MBio (March, 2018)
Jen Martynowicz (Sullivan Lab) received the 2018 Madri Scholarship (February, 2018)
Vicki Jeffers was awarded a research grant from IUSM Center for AIDS Research (January, 2018)
New publication: "Elp3 and RlmN: A tale of two mitochondrial tail-anchored radical SAM enzymes in Toxoplasma gondii" in PLOS ONE (January, 2018)
New publication: "Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency" in Cell Host & Microbe (December, 2017)
BLOG: Depriving Parasites of Their Shelter from the Storm.
Nature Reviews Microbiology: Parasite biology: Keeping Plasmodium awake
Cell Preview: Plasmodium Peekaboo: PK4 Mediates Parasite Latency
Anna Justis (Gilk Lab) was awarded her Ph.D. after successfully defending her thesis (December, 2017)
New publication: "Characterization of Plasmodium Atg3-Atg8 interaction inhibitors identifies novel alternative mechanisms of action in Toxoplasma gondii." in Antimicrobial Agents & Chemotherapy (November, 2017)
Dr. John has been selected to be the next President of ASTMH (November, 2017)
Dr. Sullivan talks about Toxoplasma, zombies and more on The Naked Scientists (October, 2017)
New publication: "Synergistic malaria vaccine combinations identified by systematic antigen screening" in PNAS (October, 2017)
New publication: "Translational Control in the Latency of Apicomplexan Parasites" in Trends Parasitol (September, 2017)
New publication: "The serine/threonine phosphatases of apicomplexan parasites" in Mol Microbiol (September, 2017)
Dr. Sullivan was interviewed for SCIENCE TRENDS (September, 2017)
New publication: "Autophagy participates in the unfolded protein response in Toxoplasma gondii" in FEMS Microbiol Lett (September, 2017)
Leo Augusto (Sullivan Lab) won a Poster Award at the 2017 Midwest Neglected Infectious Disease meeting at Notre Dame, IN (August, 2017)
Tati Clemente (Gilk Lab) won a travel award for the Midwest Microbial Pathogenesis Conference (August, 2017)
New publication: "Public antibodies to malaria antigens generated by two LAIR1 insertion modalities" in Nature (August, 2017)
Raj Gaji was awarded a 2017 research grant from the Showalter Foundation (July, 2017)
Kaice LaFavers (Arrizabalaga Lab) was awarded her Ph.D. after successfully defending her thesis (July, 2017)
New publication: “Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria” in Malar J (July, 2017)
New publication: “Developing mentorship in a resource-limited context: a qualitative research study of the experiences and perceptions of the makerere university student and faculty mentorship programme” BMC Med Educ (July, 2017)
Joe Varberg (Arrizabalaga and Sullivan Labs) was awarded his Ph.D. after successfully defending his thesis (June, 2017)
Stacey Gilk received the Randy S. Rosenthal Graduate Student Advocacy Award (June, 2017)
New publication: “The Benjamin H. Kean Travel Fellowship in Tropical Medicine: Assessment of Impact at 15 Years” in Am J Trop Med Hyg (June, 2017)
New publication: “Decrease in Numbers of Naive and Resting B Cells in HIV-Infected Kenyan Adults Leads to a Proportional Increase in Total and Plasmodium falciparum-Specific Atypical Memory B Cells” in J Immunol (Jun, 2017)
New publication: "The common parasite Toxoplasma gondii induces prostatic inflammation and microglandular hyperplasia in a mouse model" in Prostate (May, 2017)
Leah Padgett (Sullivan Lab) was awarded her Ph.D. after successfully defending her thesis (May, 2017)
New publication: “Supporting Global Health at the Pediatric Department Level: Why and How” in Pediatrics. (May, 2017)
New publication: “Clinical Comparison of Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria” in Am J Trop Med Hyg (May, 2017)
New publication: “Neurodevelopment: The Impact of Nutrition and Inflammation During Early to Middle Childhood in Low-Resource Settings”in Pediatrics (April, 2017)
New trainee grant: Lindsey Turnbull (John Lab) was selected for NIH T32 postdoctoral support (April, 2017)
New publication: "A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii" in Cell Microbiol (April, 2017)
New publication: "Toxoplasma gondii AP2IX-4 Regulates Gene Expression during Bradyzoite Development" in mSphere (March, 2017)
New publication: "Mitochondrial behavior throughout the lytic cycle of Toxoplasma gondii" in Sci Rep. (February, 2017)
New publication: "TgPRELID, a Mitochondrial Protein Linked to Multidrug Resistance in the Parasite Toxoplasma gondii" in mSphere (February, 2017)
New publication: "Treatment of Chronic Asymptomatic Plasmodium falciparum Infection Does Not Increase the Risk of Clinical Malaria upon Reinfection" in Clinical Infectious Diseases (February, 2017)
New publication: "Toxoplasma gondii AP2IX-4 regulates gene expression during bradyzoite development" in BioRxiv (Janurary, 2017)
New publication: “Elevated cholesterol in the Coxiella burnetii intracellular niche is bateriolytic” in mBio (January 2017).
New publication: "Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis" in BioRxiv (January, 2017)
New publication: "Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development" in Microbiol Mol Biol Rev. (January, 2017)
Sherri Huang (Sullivan Lab) was awarded her Ph.D. after successfully defending her thesis (January, 2017)
Jen Martynowicz (Sullivan Lab) was awarded a position on the Immunology & Infectious Disease Training Grant (January 2017)
New Publication: “Interferon-γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission” in PeerJ (January, 2017)
New publication: "Targeting of tail-anchored membrane proteins to subcellular organelles in Toxoplasma gondii" in Traffic (December, 2016).
New publication: "Phosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species" in PLoS Pathogens (December, 2016)
Matthew Muramatsu and Julie Brothwell (Nelson lab) have successfully defended their dissertation thesis!
Dr. Sullivan was a consultant for "Why Do Bacteria Develop Antibiotic Resistance?" - Everyday Elements on YouTube. (November 2016).
New publication: "Long-term Behavioral Problems in Children With Severe Malaria" in Pediatrics (October, 2016)
Minal Mulye (Gilk Lab) won second place poster at the IUSM Postdoc Symposium (October 2016)
Dr. Gilk won the 2016 IUSM Outstanding Postdoc Mentor Award (September, 2016)
PRESS RELEASE: IUSM departments create new infectious pathogens research group
New publication: "Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria" in Scientific Reports (August, 2016)
Stephen Fakoyejo's summer SRPinAM research is selected for oral presentation (August, 2016)
Jen Martynowicz is the first recipient of the Joseph and Lucille Madri Scholarship (July 2016)
Darrelle Colinot earned a Paradise Travel Award (July 2016)
Joe Varberg's PhRMA Foundation research is featured in their 2015 Annual Report .
New publication: “Interactions between the Coxiella burnetii vacuole and host endoplasmic reticulum involve the host protein ORP1L” in Cellular Microbiology (June, 2016).
Dr. Sullivan was interviewed by CNN about the health risks associated with Toxoplasma and cats (June, 2016).
New publication: "The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria" in Science Reports (June, 2016).
New publication: "Oxidative stress generated during monensin treatment contributes to altered Toxoplasma gondii mitochondrial function" in Science Reports (March, 2016)
New grant: Dr. Arrizabalaga was awarded an NIH R01 NIH to study the phosphorylation network regulating the lytic cycle of Toxoplasma gondii (March, 2016).
New grant: Drs. Sullivan and Wek were awarded an NIH R01 to study translational control in Toxoplasma gondii (March, 2016)
New publication: "Garcinol inhibits GCN5-mediated lysine acetyltransferase activity and prevents replication of the parasite Toxoplasma gondii" in Antimicrobial Agents & Chemotherapy (January, 2016).
New publication: "TgATAT-Mediated α-Tubulin Acetylation Is Required for Division of the Protozoan Parasite Toxoplasma gondii" in mSphere (January, 2016).
New trainee grant: Kaice LaFavers (Arrizabalaga Lab) was awarded a predoctoral fellowship from the American Heart Association to study the role of a secreted protein in Toxoplasma calcium signaling (December, 2015).
New grant: Dr. Gilk was awarded an NIH R21 “Reprogramming of host cell cholesterol homeostasis by Coxiella burnetii” (December, 2015).
New trainee grant: Minal Mulye (Gilk Lab) was awarded a postdoctoal fellowship from the American Heart Association to study “Lipid droplets in Q fever endocarditis" (December, 2015)
New trainee grant: Anna Justis (Gilk Lab) was selected for NIH T32 predoctoral support (December, 2015)
New publication: "An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite Toxoplasma gondii." in Mol Biol Cell (December, 2015). FEATURED ON COVER.
New publication: "Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress" in PLoS Pathogens (November, 2015)
New publication: "Preventing friendly fire in the war on microbes" in Science Translational Medicine (October, 2015)
New publication: "Guanabenz repurposed as an anti-parasitic with activity against acute and latent toxoplasmosis." in Antimicrob Agents & Chemotherapy (September, 2015).
Featured on THE SCIENTIST, FIERCE BIOTECH RESEARCH, MEDICAL DAILY, DISEASE BUZZ
Congratulations to Vicki Jeffers (Sullivan Lab) for winning the 2015 Outstanding Postdoc Award (September, 2015)
Congratulations to Leah Padgett (Sullivan Lab) for winning the 2015 Outstanding Graduate Student Volunteer Award (September, 2015)
New trainee grant: Michael Harris (Sullivan Lab) was selected for NIH T32 postdoctoral support (September, 2015).
Minal Mulye (Gilk Lab) won an abstract and poster award at the Midwest Microbial Pathogenesis Meeting (September, 2015)
Anna Justis (Gilk Lab) won an abstract award at the Midwest Microbial Pathogenesis Meeting (September, 2015)
"Played by a Parasite", co-written by Drs. Sullivan and Arrizabalaga, was published in Scientific American Special Issue, "Dogs & Cats" (Fall, 2015).
